Contributing

Why is clopidogrel and aspirin used together?

Standard

Why is clopidogrel and aspirin used together?

The combination of clopidogrel and aspirin may lower the risk for major ischemic events among patients with minor ischemic stroke or high-risk transient ischemic attack compared with aspirin alone, according to results of the POINT study.

Is ticlopidine better than clopidogrel?

Clopidogrel is at least as effective as aspirin in preventing cardiovascular events in patients with a history of vascular disease. It appears to be safer than ticlopidine, although its efficacy in acute coronary syndromes or post-coronary-stent insertion has not been reported.

Is ticlopidine an anticoagulant or antiplatelet?

Ticlopidine and clopidogrel are effective antiplatelet agents and are useful in the prevention of stroke, myocardial infarction, and vascular death in patients with vascular disease.

Why is ticlopidine not used?

Ticlopidine was previously approved for the prevention of ischemic stroke and for patients with recent coronary intervention. However, due to the incidence of severe neutropenia, aplastic anemia, and thrombotic thrombocytopenic purpura (TTP) associated with the drug, it is no longer available in the United States.

Can I take clopidogrel in the morning and aspirin at night?

Conclusions: Bedtime administration of aspirin and clopidogrel decreased morning surge of platelet aggregation while kept same antiplaelet efficay during other time of the day compared to taking these drugs at day-time.

Can I take clopidogrel and atorvastatin at the same time?

The investigators concluded that patients who took atorvastatin and clopidogrel together had almost a 2-fold—increased risk of major adverse events at 30 days compared with patients on clopidogrel alone.

What class of drug is ticlopidine?

Ticlopidine is an oral drug that inhibits the ability of platelets to clump and form blood clots. It prevents blood clots by binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors.

How does ticlopidine cause neutropenia?

The potential mechanism of ticlopidine-induced neutropenia is a toxicity from a reactive intermediate, Thiophene-S-chloride, formed by oxidation due to hydrogen peroxide or myeloperoxidase in activated neutrophils or neutrophil precursors (Fig 2).

Can ticlopidine cause thrombocytopenia?

Background One of the most unusual causes of thrombotic thrombocytopenic purpura (TTP), a life-threatening disease, is ticlopidine hydrochloride, an antiplatelet agent used to prevent strokes in high-risk populations or following coronary artery stent placement.

When was ticlopidine discontinued?

The first generic ticlopidine hydrochloride was FDA approved in 1999. As of April 2015, Roche, Caraco, Sandoz, Par, Major, Apotex, and Teva had discontinued generic ticlopidine and no ticlopidine preparations were available in the US.

What medications should not be taken with clopidogrel?

Clopidogrel may interact with other medications

  • Diabetes drug. In most cases, repaglinide should not be taken with clopidogrel.
  • Stomach acid drugs (proton pump inhibitors)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Blood thinners.
  • Drugs used to treat depression.
  • Salicylates (aspirin)
  • Opioids.

What is the best time to take clopidogrel?

You can take clopidogrel at whatever time of day you find easiest to remember, but take your doses at the same time of day each day. Most people prefer to take it in the morning, as they find this helps them to remember to take it regularly. You can take the tablet either before or after a meal.