Why is acetanilide not used as a drug anymore?
Why is acetanilide not used as a drug anymore?
Unfortunately, Acetanilide exhibited an unacceptable profile of toxic effects, the most alarming being cyanosis due to methemoglobinemia. The toxic profile prompted the search for supposedly less toxic aniline derivatives such as phenacetin.
What are the uses of aniline?
Aniline is used in rubber accelerators and anti-oxidants, dyes and intermediates, photographic chemicals, as isocyanates for urethane foams, in pharmaceuticals, explosives, petroleum refining; and in production of diphenylamine, phenolics, herbicides and fungicides.
Where can acetanilide be found?
Acetanilide is a natural product found in Dendrobium moniliforme, Dendrobium officinale, and other organisms with data available. N-phenylacetamide is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group.
What is use of acetanilide Mcq?
Acetanilide is used in the synthesis of penicillin and in other pharmaceuticals. It is also used as an antipyretic agent means fever reducing agent.
Which of the following drug is synthesized from acetanilide?
Acetanilide is also a building block in the synthesis of penicillin, an important antibiotic.
What are uses of phenol?
What is phenol used for?
- Phenol Injection. Phenol can be injected into your muscles to treat a condition known as muscle spasticity.
- Chemical matrixectomy. Phenol is commonly used in surgeries for ingrown toenails.
- Vaccine preservative.
- Sore throat spray.
- Oral analgesics.
- Phenol derivatives.
- Phenol liquid.
- Soap and antiseptic.
Does acetanilide dissolve in water?
Water
BenzeneEthanolAcetoneDiethyl ether
Acetanilide/Soluble in
Why is acetanilide used instead of aniline?
Question: Acetanilide is used instead of aniline for the nitration because aniline has an unwanted side reaction.
What is acetanilide made of?
Structure & Chemical Formula Acetanilide is an organic chemical compound (meaning it’s composed of carbon and hydrogen mostly) that is classified as an amide in terms of its functional group. This means that it has the carbonyl group (carbon-oxygen double bond) bonded directly to a nitrogen atom.
What is acetanilide used for in Chemical Engineering?
It has also found uses in the intermediation in rubber accelerator synthesis, dyes and dye intermediate synthesis, and camphor synthesis. Acetanilide is used for the production of 4-acetamidobenzenesulfonyl chloride, a key intermediate for the manufacture of the sulfa drugs.
What are the side effects of acetanilide?
Excessive or prolonged use engenders toxic side effects: it interferes with the function of hemoglobin, the oxygen-carrying pigment of the blood. In the body acetanilide is mostly converted to acetaminophen, which has replaced acetanilide in therapy because it is less likely to induce blood disorders.
Does acetanilide have aniline?
You see, it was found that acetanilide samples always had an impurity of aniline in them, which is what acetanilide was made from. The problem with aniline being present as an impurity is that aniline is a carcinogen (cancer-causing agent).
How do you make acetanilide?
Acetanilide can be described by two resonance structures, with the one that places a positive charge on the nitrogen atom helping to explain why it is non-basic. In terms of how acetanilide is synthesized, it’s most commonly made by reacting aniline with either acetyl chloride or acetic anhydride.