Why are anticholinergic drugs contraindicated in glaucoma?
Why are anticholinergic drugs contraindicated in glaucoma?
Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. This can cause glaucoma in individuals with narrow anterior chamber angles by dilating the pupil and causing pupillary block.
What medications should be avoided with glaucoma?
Closed-Angle Glaucoma: Medicines to Avoid
- Antihistamines and decongestants.
- Asthma medicines.
- Motion sickness medicines.
- Some medicines used to treat depression (tricyclic antidepressants).
Do anticholinergics increase intraocular pressure?
Administered parenterally, the anticholinergics have little effect on intraocular pressure except in patients with acute narrow-angle glaucoma, in whom dangerously high intraocular pressures may develop.
Which of the following anticholinergic agent is preferred in the treatment of glaucoma?
Physostigmine salicylate has FDA approval for use in the treatment of glaucoma and the treatment of anticholinergic toxicity. It is useful to treat the central nervous system effects of anticholinergic toxicity due to its ability to cross the blood-brain barrier.
Which category of drug may exacerbate glaucoma?
Drugs that cause or exacerbate open-angle glaucoma are mostly glucocorticoids.
What drugs increase risk of glaucoma?
Medication classes addressed in this review that may increase the risk of angle closure glaucoma include anticholinergics, adrenergic agonists, certain classes of antidepressants, sulfonamides, and topiramate.
How do anticholinergics affect vision?
Direct anticholinergic effects can lead to blurred vision by causing mydriasis and cycloplegia. There is an increased risk of open-angle glaucoma. There have also been reports of lenticular opacities with some phenothiazines.
Do anticholinergics cause pupil dilation or constriction?
Answer: Anticholinergic exposure paralyzes pupillary constrictor muscles and causes dilated pupils that do not react to light. Think about when you go to the eye doctor’s office.
Which drug is appropriate for a patient with glaucoma?
Prostaglandins. These increase the outflow of the fluid in your eye (aqueous humor), thereby reducing your eye pressure. Medicines in this category include latanoprost (Xalatan), travoprost (Travatan Z), tafluprost (Zioptan), bimatoprost (Lumigan) and latanoprostene bunod (Vyzulta).
Which drug is an effective anticholinergic for ophthalmic use?
This medication is used before eye examinations (such as refraction) and to treat certain eye conditions (such as uveitis). It belongs to a class of drugs known as anticholinergics. Atropine works by widening (dilating) the pupil of the eye.