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Who invented tacrolimus?

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Who invented tacrolimus?

Tohru KinoTacrolimus / InventorTohru Kino is a Japanese chemist and pharmacologist, best known for his discovery of tacrolimus.
While working for Fujisawa Pharmaceutical Company in the 1980s, Kino and his colleagues found that FK-506, Wikipedia

Who manufactures tacrolimus?

Currently, five companies manufacturer generic tacrolimus in the U.S. (Accord Healthcare, Dr. Reddy Labs, Panacea Biotec Ltd., Sandoz, and Mylan); Sandoz also makes a branded generic drug (Hecoria).

What is tacrolimus capsules used for?

Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, heart, or lung). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

What is the brand name for tacrolimus?

Tacrolimus comes as the brand-name drugs Astagraf XL, Envarsus XR, Prograf, and Protopic. Like the different forms of generic tacrolimus, these brand-name drugs do not all have the same uses.

How was tacrolimus discovered?

It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.

When was tacrolimus introduced?

Tacrolimus was discovered in 1987; it was among the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.

Where is tacrolimus made?

Tacrolimus was discovered in 1987; it was among the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975. It is produced by a soil bacterium, Streptomyces tsukubensis.

What is the generic for tacrolimus?

Prograf is the brand name while tacrolimus is the generic name. Tacrolimus is also available as an ointment called Protropic. Tacrolimus is an immunosuppressant. The oral form is used to suppress the immune system in people who have had an organ transplant.

What are side effects of tacrolimus?

Tacrolimus may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • diarrhea.
  • constipation.
  • nausea.
  • vomiting.
  • heartburn.
  • stomach pain.
  • loss of appetite.

Is tacrolimus a steroid?

PROTOPIC (TACROLIMUS) Protopic is different because it is not a steroid-containing product and, therefore, will not cause any of the side effects of topical steroids. For this reason, it has some advantages over the prior treatment for dermatitis. Protopic is a new type of medication called an immunomodulator.

What is the generic name for tacrolimus?

What type of drug is tacrolimus?