What percentage of the population has ankylosing spondylitis?

What percentage of the population has ankylosing spondylitis?

About 300,000 Americans (less than one percent of the adult population) have ankylosing spondylitis. The disease is three times more common in whites than in African Americans.

Who is most likely to get ankylosing spondylitis?

Men are more likely to develop ankylosing spondylitis than are women. Onset generally occurs in late adolescence or early adulthood. Most people who have ankylosing spondylitis have the HLA-B27 gene. But many people who have this gene never develop ankylosing spondylitis.

What race has the highest percentage of ankylosing spondylitis cases?

Axial spondyloarthritis (AxSpA) and ankylosing spondylitis (AS) are known to have a lower prevalence in Blacks and Africans than in other ethnic groups [1–4]. AS is three times more common and AxSpA nearly twice as common in American Whites than in American Blacks [1, 4].

What are the odds of getting ankylosing spondylitis?

If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have. It is estimated that between 5 to 20% of children with this gene will then go on to develop AS.

What percentage of people have HLA-B27?

Genetic Testing The HLA-B27 gene marker is found in approximately 3% to 8% of the population, but it is found in more than 90% of patients with ankylosing spondylitis and in 50% to 80% of patients with other SpAs.

How many people have ankylosing spondylitis worldwide?

The prevalence of AS is generally believed to be between 0.1% and 1.4% globally, although it is difficult to be certain, as few prevalence studies have been conducted compared with other rheumatic disorders such as RA [3].

Does ankylosing spondylitis run in families?

Inheritance. Although ankylosing spondylitis can occur in more than one person in a family, it is not a purely genetic disease. Multiple genetic and environmental factors likely play a part in determining the risk of developing this disorder.

Do black people get ankylosing spondylitis?

Ankylosing spondylitis is three times less common in American blacks than in whites. It is extremely rare in African blacks of unmixed ancestry.

What ethnicities have HLA-B27?

By race/ethnicity, the prevalence of B27 was 7.5% (95% CI 5.3–10.4) among non-Hispanic whites and 3.5% (95% CI 2.5–4.8) among all other US races/ethnicities combined. In Mexican Americans, the prevalence was 4.6% (95% CI 3.4–6.1).

Does HLA-B27 run in families?

The clearest risk factors involve inherited genes and family history: A gene called HLA-B27 is found in 85% to 95% of people with ankylosing spondylitis, though some estimates are lower. Experts estimate only about 8% of people around the world have this gene. Not everyone who has HLA-B27 will get AS.

What percentage of people with ankylosing spondylitis have HLA-B27?

HLA-B27 is found in 88% of patients with ankylosing spondylitis. The chance that an HLA-B27 patient will develop spondyloarthritis or eye disease is 1 in 4.