What is the role of hypoxanthine-guanine phosphoribosyltransferase?
What is the role of hypoxanthine-guanine phosphoribosyltransferase?
Purine Salvage The enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is one of the central enzymes that recycle the building blocks of RNA and DNA. It attaches a purine base (either guanine or hypoxanthine, a modified form of adenine) to a sugar, creating a nucleotide.
What is hypoxanthine-guanine phosphoribosyltransferase deficiency?
Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency is a hereditary disorder of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzyme deficiency.
What is hypoxanthine and xanthine?
Accumulated hypoxanthine is a potential generator of oxygen free radicals via endogenous enzymatic reactions, e.g., the conversion of hypoxanthine to xanthine and uric acid by xanthine oxidase, a form of the molybdoflavoenzyme xanthine oxyreductase [105,108].
What is hypoxanthine used for?
Hypoxanthine is a necessary additive in certain cell, bacteria, and parasite cultures as a substrate and nitrogen source. For example, it is commonly a required reagent in malaria parasite cultures, since Plasmodium falciparum requires a source of hypoxanthine for nucleic acid synthesis and energy metabolism.
Which enzyme is deficient in gout?
Due to a deficiency of the digestive enzyme uricase, people who have gout are unable to break down and excrete uric acid, allowing levels of it to build up in the blood, a condition called hyperuricemia.
What reaction is catalyzed by Phosphoribosyltransferase?
Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyzes the reversible formation of IMP and GMP from their respective bases hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP).
What enzyme deficiency causes gout?
Hypoxanthine:guanine phosphoribosyltransferase deficiency is known to cause hyperuricaemia and gout.
How long do people live with Lesch-Nyhan syndrome?
With optimal medical care, individuals with Lesch-Nyhan disease typically live into their third or even fourth decade of life. Few patients live beyond 40 years.
Is hypoxanthine a purine?
Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine.
What is the structure of hypoxanthine?
C5H4N4OHypoxanthine / Formula
What is guanine used for?
In the cosmetics industry, crystalline guanine is used as an additive to various products (e.g., shampoos), where it provides a pearly iridescent effect. It is also used in metallic paints and simulated pearls and plastics. It provides shimmering luster to eye shadow and nail polish.
What is hypoxanthine in fish?
Hypoxanthine is regarded as the major catabolite of adenosine triphosphate (ATP) and it is a useful indicator of freshness because of its gradual accumulation in seafood. Hx value rapidly increases in ice storage and the content of the muscle is used for the determination of the post-mortem age in seafood.
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