What is the meaning of indole compounds?
What is the meaning of indole compounds?
Definition of indole : a crystalline alkaloid compound C8H7N that is a decomposition product of proteins containing tryptophan, that can be made synthetically, and that is used in perfumes also : a derivative of indole.
What is the indoles function?
Indole modulates oxidative stress, intestinal inflammation, and hormone secretion in animals, and it controls plant defense systems and growth. Insects and nematodes can recognize indole, which controls some of their behavior.
What is indole in organic chemistry?
Introduction: ➢ Indole is a benzo[b]pyrrole formed by the fusion of benzene ring. to the 2,3 positions of pyrrole nucleus. ➢ The word “Indole” is derived from the word India, as the heterocycle was first isolated from a blue dye “Indigo” produced in India during sixteenth century.
What is indole family?
best-known indole-containing compounds are the indole alkaloids, which have been isolated from plants representing more than 30 families. The mushroom hallucinogens psilocin and psilocybin, the ergot fungus alkaloids, the drugs reserpine and yohimbine, and the poison strychnine all belong to this group.
What is Indolic group?
Indole is an aromatic heterocyclic organic compound with formula C8H7N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.
What produces indole?
Indole is generated by reductive deamination from tryptophan via the intermediate molecule indolepyruvic acid. Tryptophanase catalyzes the deamination reaction, during which the amine (-NH2) group of the tryptophan molecule is removed. Final products of the reaction are indole, pyruvic acid, ammonium (NH4+) and energy.
What drugs are indoles?
Most drugs on the market contain the indole substructure. These include indomethacin, ergotamine, frovatriptan, ondansetron, and tadalafil.
How do bacteria produce indoles?
Indole Biosynthesis and Influencing Factors For indole-producing bacteria like Escherichia coli, the primary resource for indole production is an amino acid tryptophan: an enzyme tryptophanase encoded by gene tnaA reduces tryptophan to pyruvate, ammonia, and indole in a reversible reaction.
What is the structure of indole?
C8H7NIndole / Formula
Is indole a functional group?
The indole functional group absorbs strongly in the near ultraviolet part of the spectrum. The indole nitrogen can hydrogen bond donate, and as a result, tryptophan, or at least the nitrogen, is often in contact with solvent in folded proteins.
Who discovered Skatole?
Emil Fischer
(1) The Fischer Indole Synthesis is the reaction of a phenylhydrazine with an aldehyde or ketone using an acid catalyst. It was invented by Emil Fischer in 1883.
Which of following compound is called Benzopyrrole?
indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.