What is the function of the translocon?
What is the function of the translocon?
Abstract. The membrane of the endoplasmic reticulum (ER) in human cells harbors the protein translocon, which facilitates membrane insertion and translocation of almost every newly synthesized polypeptide targeted to organelles of the secretory pathway.
What is the trap complex?
TRAP is a ubiquitous protein complex present in all eukaryotes [28]; in mammalians, it is a heterotetrameric complex with a molecular weight of approximately 90 kDa. All four subunits, previously known as signal sequence receptors (ssr), are membrane proteins: α (ssr1), β (ssr2), γ (ssr3) and δ (ssr4).
What does the ER translocon contain?
Molecular Cell Biology The Sec61 translocon on the ER membrane is a highly conserved multi-subunit protein complex that consists of three subunits, Sec61α, Sec61β, and Sec61γ (of 476, 96, and 68 amino acid residues, respectively) in eukaryotic cells (Görlich and Rapoport, 1993; Osborne et al., 2005; Table 1).
What do you mean by translocon?
The translocon (also known as a translocator or translocation channel) is a complex of proteins associated with the translocation of polypeptides across membranes.
Is mRNA involved in co translational translocation?
In co-translational translocation, the entire ribosome/mRNA complex binds to the outer membrane of the rough endoplasmic reticulum (ER) and the new protein is synthesized and released into the ER; the newly created polypeptide can be stored inside the ER for future vesicle transport and secretion outside the cell, or …
How does the translocon open?
The ribosome docks with the translocon where the signal sequence (triangle) is recognized. This then opens the channel allowing the protein to go through.
What is the difference between translation and translocation?
Translation is the process of formation of protein from RNA. Translocation is the movement of materials in plants from the leaves to other parts of the plant.