What is the example of V-ATPase?

What is the example of V-ATPase?

V-ATPases are also found in the plasma membranes of a wide variety of cells such as intercalated cells of the kidney, osteoclasts (bone resorbing cells), macrophages, neutrophils, sperm, midgut cells of insects, and certain tumor cells.

What is the function of V-ATPase?

V-ATPases are proton pumps that function to acidify intracellular compartments in all eukaryotic cells, and to transport protons across the plasma membrane of certain specialized cells.

What happens if ATP synthase is defective?

The insufficient ATP synthase phosphorylating capacity with respect to the respiratory chain results in an impaired energy provision and an increased ROS production due to an elevated mitochondrial membrane potential (1,16).

What is mitochondrial ATPase?

Introduction. The mitochondrial ATP synthase is a membrane protein complex that generates most of the ATP in eukaryotic cells. The synthesis of ATP from ADP and inorganic phosphate proceeds via rotary catalysis, which uses the energy of the electrochemical gradient across the mitochondrial inner membrane.

What is an F-type ATPase?

F-ATPase, also known as F-Type ATPase, is an ATPase/synthase found in bacterial plasma membranes, in mitochondrial inner membranes (in oxidative phosphorylation, where it is known as Complex V), and in chloroplast thylakoid membranes.

Where is ATPase found?

P-ATPases (E1E2-ATPases) are found in bacteria, fungi and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes. E-ATPases are cell-surface enzymes that hydrolyze a range of NTPs, including extracellular ATP.

How do mitochondrial diseases affect ATP production?

Mitochondrial disease leads to impaired respiratory chain function and reduced ATP production. The aim of this study was to compare disturbances in mitochondrial function by measuring ATP synthesis in fibroblasts derived from patients with nDNA and mtDNA defects.

What is Leighs Disease?

In Leigh’s disease, genetic mutations in mitochondrial DNA interfere with the energy sources that run cells in an area of the brain that plays a role in motor movements. The primary function of mitochondria is to convert the energy in glucose and fatty acids into a substance called adenosine triphosphate ( ATP).

Where is ATPase found in mitochondria?

inner membrane
The ATP synthase is a mitochondrial enzyme localized in the inner membrane, where it catalyzes the synthesis of ATP from ADP and phosphate, driven by a flux of protons across a gradient generated by electron transfer from the proton chemically positive to the negative side.

What is the role of complex V in ATP production during aerobic respiration?

Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria.

What happen if ATPase would be inhibited?

Since Na,K-ATPase is important for maintaining various cellular functions, its inhibition could result in diverse pathologic states. Inhibition of Na,K-ATPase causes high intracellular Na+ ion levels and subsequent increases in intracellular Ca2+ ion through the Na+/Ca2+ exchanger [16].