What is pteridine ring explain?
What is pteridine ring explain?
[ tĕr′ĭ-dēn′ ] Any of a group of organic compounds having two fused six-member rings each containing two nitrogen atoms and four carbon atoms. One of the rings is a pyrimidine, the other a pyrazine. Pteridines include folic acid and the pigments of butterfly wings.
What is pteridine precursor?
The pteridine synthesis pathway has different branches, one of them leading to the formation of sepiapterin as a precursor for different types of pteridine pigments. Another branch leads to the formation of tetrahydrobiopterin (Figure 4(b)).
Where is pteridine found?
Pteridines were first discovered in the pigments of butterfly wings2 (from Greek pteros = wing) and are composed of fused pyrimidine and pyrazine rings containing a wide variety of substitutions on this structure. In pterins, the pyrimidine ring has a carbonyl oxygen and an amino group.
What does aminopterin inhibit?
As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis.
What is thiazole ring?
Thiazoles are structurally similar to imidazoles, with the thiazole sulfur replaced by nitrogen. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.
What is Pteridine made of?
Pteridine is an aromatic chemical compound composed of fused pyrimidine and pyrazine rings. A pteridine is also a group of heterocyclic compounds containing a wide variety of substitutions on this structure.
What elements make up folic acid?
Folic acid (pteroylglutamic acid) is composed of three large sub-components. These are the pteridine ring, para-amino benzoic acid, and glutamic acid.
Which of the following vitamins contain pteridine ring *?
Folic acid consists of three moieties: the pterin (or pteridine) ring, which is conjugated to PABA by a methylene bridge, which is in turn joined to a glutamic residue via a peptide bond. Folic acid is the fully oxidized monoglutamyl form of this vitamin that is used commercially in supplements and in fortified foods.
What is the function of aminopterin?
Aminopterin is an antibiotic that effectively blocks the de novo pathway, forcing all the cells to use the salvage pathway.
Why is aminopterin used?
Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950’s its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment of psoriasis.
How can we synthesis thiazole?
By combining phosphorus pentasulfide with triethylamine, 5-aryl thiazoles are formed. Unsubstituted thiazoles are formed by combining chloroacetaldehyde with thioformamide. From thioamides – Thioamides are converted to thiazole derivatives when second-chloroxiranes are substituted.