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What is pitavastatin calcium used for?

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What is pitavastatin calcium used for?

Pitavastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

What is the brand name of pitavastatin?

Highlights for pitavastatin Pitavastatin oral tablet is available as a generic drug and as brand-name drugs. Brand names: Livalo, Zypitamag. Pitavastatin comes only as a tablet you take by mouth. Pitavastatin is a drug called a statin.

What type of drug is pitavastatin?

Pitavastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.

Is pitavastatin calcium a statin?

Abstract. Background: Pitavastatin calcium is a new addition to the class of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (“statins”) approved for use in the United States for the treatment of primary hyperlipidemia and mixed dyslipidemia.

What are the adverse effects of pitavastatin?

Common side effects of Livalo include:

  • muscle pain,
  • back pain,
  • joint pain,
  • pain in your arms and legs,
  • diarrhea,
  • constipation,
  • skin rash,
  • headache,

What is the half-life of pitavastatin?

Excretion A mean of 15% of radioactivity of orally administered, single 32 mg 14C-labeled pitavastatin dose was excreted in urine, whereas a mean of 79% of the dose was excreted in feces within 7 days. The mean plasma elimination half-life is approximately 12 hours.

Is pitavastatin better than rosuvastatin?

Results: The mean daily dose of rosuvastatin and pitavastatin was 2.5 mg and 1.4 mg, respectively. All lipid parameters were significantly more improved in the rosuvastatin group. eGFR improved from baseline in the rosuvastatin group (p ＜ 0.0001) and showed no tendency to worsen in the pitavastatin group (p=0.2232).

Is pitavastatin a good statin?

Pitavastatin is a novel, well-tolerated statin with a noninferior or superior lipid-lowering efficacy to comparable doses of atorvastatin, simvastatin, and prava-statin in a wide range of patients with hypercholesterolemia or combined dyslipidaemia.

Does pitavastatin cause hair loss?

A. Hair loss, or alopecia, is a very rare side effect of all statin drugs. Widely prescribed in the treatment of high cholesterol, statins work by blocking the action of an enzyme the liver uses to make cholesterol. About 1% of people taking statins report hair loss.

How is pitavastatin metabolized?

Pitavastatin is metabolized by CYP2C9 and CYP2C8. Pitavastatin has a reasonable duration of action and plasma half-life (t1/2=4–5 h). Pitavastatin 9 was launched in Japan in 2003 and is being tested clinically in the US.

Is pitavastatin better than atorvastatin?

Results: Pitavastatin lowered LDL-C levels from baseline by 37% compared with 46% in the atorvastatin group (p < 0.001). The reduction of total cholesterol (TC) levels from baseline was significantly different between the pitavastatin (28%) and atorvastatin (32%) groups (p = 0.005).

How is pitavastatin different from other statins?

In vitro studies show that, compared with other statins, pitavastatin has a greater HMG-CoA reductase inhibitor activity, induces greater LDL receptor expression and LDL uptake, and more effectively inhibits very-low-density lipoprotein (VLDL) secretion from HepG2 cells [Ose et al.