What is HLA-DR antibodies?
What is HLA-DR antibodies?
HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes. Applications Reported: The LN3 antibody has been reported for use in flow cytometric analysis.
What is HLA-DR a marker for?
HLA-DR is recognized as a marker of T cell activation (12, 13) and has been shown to be increased in CTLs in autoimmune diseases (14) and in patients with HIV infection (15).
Where is HLA-DR expressed?
antigen-presenting cells
HLA-DR is a molecule typically expressed by antigen-presenting cells and is associated with antigen presentation. Interestingly HLA-DR is also expressed on T cells and has been associated with T cell activation. However, why and how activated T cells express HLA-DR is not fully understood.
Do all cells express HLA-DR?
HLA-DR molecules are found on antigen-presenting cells (APC), i.e. dendritic cells, B lymphocytes, monocytes, macrophages, Langerhans cells and thymic epithelial cells. They are also expressed on activated T cells, but not on granulocytes, platelets, or red blood cells.
What are HLA-DR positive cells?
Abstract. A population of heterogeneous HLA-DR positive cells has been identified in the human placenta and decidua using immunochemical and histochemical methods. These cells are found in three areas: the subepithelial layer of the amnion, the decidua, and more sparsely within the chorionic villous stroma.
What is the HLA-DR gene?
The HLA-DRB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body’s own proteins from proteins made by foreign invaders such as viruses and bacteria.
Do B cells express HLA-DR?
By contrast, HLA-DO expression was only observed in B cells and not in monocytes.
How do you know if you have the HLA-DR gene?
To find out if you are a carrier with the HLA – DR gene there’s a blood test one can get called HLA DR typing. The word “antigen” shows up both in Human Leukocyte ANTIGEN and in the definition of toxin. In very simple terms, an antigen is a molecule which can produce an immunologic response in the body.
Do macrophages express HLA-DR?
The HLA-DR antigen was demonstrated by the mouse monoclonal antibody OKIa by a peroxidase-antiperoxidase method performed on glass slides. No differences were found in the percentage of alveolar macrophages that expressed DR antigens between the five study groups.
How many people have the HLA-DR gene?
Unbeknownst to many, the HLA-DR gene affects between 40% and 60% of the world’s population.
What is HLA disease?
An HLA disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the specific disease compared to the frequency in individuals without the disease. This is expressed as a relative risk. For example, 80-90% of patients with ankylosing spondylitis have HLA-B27.