What is Fexinidazole used for?
What is Fexinidazole used for?
Fexinidazole is an orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by T.
WHO makes fexinidazole?
About DNDi Since its creation in 2003, DNDi has delivered eight treatments. Fexinidazole is the first new chemical entity to be successfully developed by DNDi.
What is trypanosomiasis disease?
Human African trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease. It is caused by infection with protozoan parasites belonging to the genus Trypanosoma.
How do you get rid of sleeping sickness?
Prevention & Control
- Wear long-sleeved shirts and pants of medium-weight material in neutral colors that blend with the background environment. Tsetse flies are attracted to bright or dark colors, and they can bite through lightweight clothing.
- Inspect vehicles before entering.
- Avoid bushes.
- Use insect repellent.
What type of drug is Fexinidazole?
Tinidazole belongs to the group of medicines called antiprotozoals. These medicines are used to treat infections caused by protozoa (tiny, one-celled animals). This medicine is available only with your doctor’s prescription.
How was Fexinidazole discovered?
The search began in 2005, when DNDi, in collaboration with the Swiss Tropical and Public Health Institute, undertook an extensive compound mining exercise to search for anti-parasitic activity and rediscovered fexinidazole, whose development had been shelved by Hoechst AG (now Sanofi) in the 1980s.
When did MSF start research into a new drug Fexinidazole for Trypanosomiasis?
The drug has entered first-in-human phase I studies in September 2009. Fexinidazole is the first new clinical drug candidate with the potential for treating advanced-stage sleeping sickness in thirty years.
What are the symptoms of trypanosomiasis?
Fever, severe headaches, irritability, extreme fatigue, swollen lymph nodes, and aching muscles and joints are common symptoms of sleeping sickness. Some people develop a skin rash. Progressive confusion, personality changes, and other neurologic problems occur after infection has invaded the central nervous system.
What 3 types of diseases does Trypanosoma cause?
Trypanosomes infect a variety of hosts and cause various diseases, including the fatal human diseases sleeping sickness, caused by Trypanosoma brucei, and Chagas disease, caused by Trypanosoma cruzi.
What is the drug of choice for sleeping sickness?
From the first decade of this century arsenicals have been the most universal and most effective drugs for all cases of sleeping sickness. Melarsoprol, introduced in the 1940s, remains the most universal of these compounds.
Is there a vaccine for sleeping sickness?
A Trypanosomiasis vaccine is a vaccine against trypanosomiasis. No effective vaccine currently exists, but development of a vaccine is the subject of current research. The Bill & Melinda Gates Foundation has been involved in funding research conducted by the Sabin Vaccine Institute and others.
How many days should I take tinidazole?
Adults—2 grams (g) once a day for 3 to 5 days. Children older than 3 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 50 milligrams (mg) per kilogram (kg) of body weight per day (up to 2 g per day) for 3 to 5 days.