What is CD10 antibody?
What is CD10 antibody?
Description. CD10 is a 100 kD neutral endopeptidase and a member of the metalloprotease family. It is a type II transmembrane protein also known as common acute lymphoblastic leukemia antigen (CALLA), enkephalinase, and neprilysin. CD10 is expressed on B cell precursors, T cell precursors, and neutrophils.
What is CD10 stain?
CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology.
How does immunohistochemistry work?
A laboratory method that uses antibodies to check for certain antigens (markers) in a sample of tissue. The antibodies are usually linked to an enzyme or a fluorescent dye. After the antibodies bind to the antigen in the tissue sample, the enzyme or dye is activated, and the antigen can then be seen under a microscope.
How are immunohistochemistry antibodies made?
Antibody types Monoclonal antibodies are made by injecting the animal and then taking a specific sample of immune tissue, isolating a parent cell, and using the resulting immortalized line to create antibodies. This causes the antibodies to show specificity for a single epitope.
What does CD10 positive mean?
The CD10 positive stromal cells are present at the cancer cells invasive front suggests the interaction between breast cancer cells and CD10-positive stromal cells. Moreover, presence of CD10 on stromal cells positively correlates with nodal metastasis, tumor grade, tumor size, lymph node and worsening prognosis.
What cells are CD10 positive?
Among hematopoietic cells, CD10 expression is found in granulocytes and in B and T lymphocytes at particular stages of maturation. CD10 expression within the B-cell lineage has been very well characterized. Benign CD10+ B cells include B lymphoblasts as well as mature germinal center B cells (1, 18).
What does CD10 negative mean?
CD10-positive acute lymphoblastic leukaemia cells were cycling cells with elevated c-myc levels and propensity to apoptosis, whereas CD10-negative acute lymphoblastic leukaemia cells had lower cycling capacities and c-myc levels, and were resistant to apoptosis in vitro.
What does CD10 positive mean in lymphoma?
Some forms of DLBCL can also be CD10-positive. Positive CD10 expression in more than 30 percent of cancer cells classifies a patient with DLBCL as having a particular subtype (GC, or germinal center type), which has a better overall survival rate than that the non-GC phenotype.