What is a high grade serous carcinoma?
What is a high grade serous carcinoma?
High-grade serous carcinoma (HGSC) is a type of tumour that arises from the serous epithelial layer in the abdominopelvic cavity and is mainly found in the ovary. HGSCs make up the majority of ovarian cancer cases and have the lowest survival rates.
What is low grade serous carcinoma?
Low grade serous cancer is a type of carcinoma (epithelial cell cancer). It is usually hormone receptor positive (estrogen +/- progesterone). Epithelial ovarian cancer is the most common type of ovarian cancer. Approximately 10% of epithelial serous ovarian cancers are low-grade.
Is ovarian tumor cancerous?
Most ovarian germ cell tumors are benign, but some are cancerous and may be life threatening. Less than 2% of ovarian cancers are germ cell tumors. Overall, they have a good outlook, with more than 9 out of 10 patients surviving at least 5 years after diagnosis.
What is the most common histopathological type of ovarian carcinoma?
HGSCs are by far the most common histologic subtype, accounting for over 50% of all ovarian carcinomas. Most HGSCs arise de novo from tubal-ovarian epithelium, do not appear to be associated with macroscopic precursors, and manifest with widely disseminated disease at presentation.
Can you survive high-grade serous carcinoma?
Outcomes for patients with this type of ovarian cancer vary on an individual basis; currently, the median overall survival for patients with high-grade serous ovarian carcinoma is about 40 months.
How long can you live with serous carcinoma?
Background: Advanced-stage (III/IV) uterine papillary serous carcinoma (UPSC) has a median overall survival (OS) of ~ 3 yrs.
Can low grade serous carcinoma be cured?
Low-grade serous carcinoma is relatively chemo-resistant. Surgery is therefore the cornerstone of treatment for LGSOC, both as first-line therapy and to treat recurrence. Standard of care in first-line therapy remains primary cytoreductive surgery followed by platinum-based chemotherapy with or without bevacizumab.
What is the difference between high-grade and low grade serous carcinoma?
Low-grade tumors are indolent and have better outcome than high-grade tumors. In contrast, high-grade serous carcinomas have high-grade nuclei and numerous mitotic figures. Identification of a precursor lesion in the ovary has been elusive and therefore the origin of ovarian carcinoma has been described as de novo.
What is the histology of ovary?
Each ovary is typically about 3 centimeters long, 1.5 centimeters wide, and 1 centimeter thick, with a thin outer capsule. The capsule is made up of a thin layer of simple cuboidal epithelium that’s only one cell thick, and an underlying dense layer of connective tissue called the tunica albuginea.