What does TET2 gene do?
What does TET2 gene do?
TET2 has pleiotropic roles in hematopoiesis, including stem-cell self-renewal, lineage commitment and terminal differentiation of specific lineages. The TET2 gene is highly expressed in HSCs and in progenitor cells, and is downregulated with differentiation.
What does TET2 stand for?
Tet methylcytosine dioxygenase 2 (TET2; also known as ten-eleven translocation 2) is a gene that codes for methylcytosine dioxygenase TET2, a protein involved in epigenetic regulation of myelopoeisis (Gene 2014; PMID: 24220273).
Is TET2 a tumor suppressor?
Thus, the tumor suppressor role of TET2 has been extensively documented, especially in myeloid lineages.
What does DNA demethylation do?
Active DNA demethylation refers to an enzymatic process that removes or modifies the methyl group from 5mC. By contrast, passive DNA demethylation refers to loss of 5mC during successive rounds of replication in the absence of functional DNA methylation maintenance machinery.
What chromosome is TET2 on?
chromosome 4q24
TET2 gene, a member of the TET family of enzymes, is located on chromosome 4q24, and its protein product TET2 modulates DNA hydroxymethylation by converting 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) to promote DNA demethylation (3).
What is the ATM gene responsible for?
The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide.
What causes TET2 mutation?
TET2 is widely affected by mutations in myeloid neoplasms, and is one of the most commonly mutated genes in CHIP [9,32,34]. Somatic TET2 mutations are present in approximately 50% of chronic myelomonocytic leukemia (CMML; an MDS/MPN) cases, ~30% of MDS, and ~10% of AML [8].
Is Tet a proto oncogene or tumor suppressor gene?
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Oncogene. 2015 Aug 6;34(32):4168-76.
Is DNA methylation good or bad?
DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases.
Why is methylation important in the body?
The methylation cycle helps us to operate both physically and mentally, so it may not be surprising that many different functions in the body use this process. Such functions include nervous, cardiovascular and immune system activity,5-8 as well as energy production, heavy-metal detoxification and hormone balance.
What is DNMT3A mutation?
DNMT3A mutations are recurrent in patients with AML and are associated with poor event-free and overall survival, independently of age and the presence of FLT3 or NPM1 mutations and regardless of the type of mutation or genetic location.
What percentage of people have the ATM gene mutation?
It is estimated that A-T affects 1 in 40,000 to 1 in 100,000 people. The chance that a person is a carrier of a single ATM gene mutation is about 1%, or 1 in 100.
https://www.youtube.com/watch?v=7uF3sydanQk