What does NF kappa B do?

What does NF kappa B do?

NF-κB regulates the expression of a large array of genes involved in different aspects of atherosclerotic pathogenesis. In vascular endothelial cells, NF-κB mediates induction of pro-inflammatory cytokines, chemotactic factors and adhesion molecules, thereby promoting monocyte recruitment and disease progression.

What gene is NFKB on?

NF-κB is a key transcription factor of M1 macrophages and is required for induction of a large number of inflammatory genes, including those encoding TNF-α, IL-1β, IL-6, IL-12p40 and cyclooxygenase-2.

How does NFKB induce gene expression?

The cytokine tumor necrosis factor (TNF) initiates tissue inflammation, a process mediated by the NF-κB transcription factor. In response to TNF, latent cytoplasmic NF-κB is activated, enters the nucleus, and induces expression of inflammatory and anti-apoptotic gene expression programs.

Is NF kappa BA transcription factor?

NF-kappa B is one of the best-characterized transcription factors. It is expressed ubiquitously and regulates the expression of many genes, most of which encode proteins that play an important and often determining role in the processes of immunity and inflammation.

What is nuclear factor kappa B NF-κB doing in and to the mitochondrion?

NF-κB and Mitochondrial Gene Expression Nuclear factor kappa B is a known regulator of gene expression – both negatively and positively (Mattson et al., 2000). However, how NF-κB regulates or influences nuclear-encoded mitochondrial gene expression is less understood.

What is nuclear factor kappa B NF-κB doing in and to the mitochondria?

Is NF-kB pro apoptotic?

Thus NF-kB has both proapoptotic and antiapoptotic functions within a single cell type. As mentioned above, IkBa phosphorylation is essential for NF-kB activation.

Do all cells have NF-kB?

NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection.

How is NF-kB activated?

Activation process (canonical/classical) Activation of the NF-κB is initiated by the signal-induced degradation of IκB proteins. This occurs primarily via activation of a kinase called the IκB kinase (IKK).

What is I kappa B alpha?

I kappaB alpha is an inhibitor protein that prevents nuclear transport-and activation of the transcription factor NF-kappaB. In acute inflammation, NF-kappaB is activated and increases the expression of several pro-inflammatory cytokine and chemokine genes. Glucocorticoids counteract this process.