What does imetelstat treat?
What does imetelstat treat?
Imetelstat Is Effective Treatment for Patients with Intermediate-2 or High-Risk Myelofibrosis Who Have Relapsed on or Are Refractory to Janus Kinase Inhibitor Therapy: Results of a Phase 2 Randomized Study of Two Dose Levels. Blood (2018) 132 (Supplement 1): 685.
Who makes imetelstat?
Creation of Imetelstat Imetelstat was created at Geron, as a 13-mer oligonucleotide. It is a competitive inhibitor of telomerase enzymatic activity. The unique mechanism of action (MOA) of imetelstat has the potential to transform the standard of care in hematologic malignancies.
What is myelofibrosis?
Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body’s normal production of blood cells. Myelofibrosis causes extensive scarring in your bone marrow, leading to severe anemia that can cause weakness and fatigue.
Do Normal cells have telomerase?
Normal human cells have lower telomerase activity and usually have longer telomeres than cancer cells. The main point of anti-telomerase therapy is the selective destruction of cancer cells while minimizing the effect on normal cells (due to the presence of longer telomeres compared to cancer cells).
What is a Geron?
Geron, an elder (from the Greek “γέρων”) of an Orthodox monastery (starets in Russian)
What is the end stage of myelofibrosis?
The end result is usually a lack of red blood cells — which causes the anemia characteristic of myelofibrosis — and an overabundance of white blood cells and varying levels of platelets. In people with myelofibrosis, the normally spongy bone marrow becomes scarred.
How long will I live with myelofibrosis?
Transcript:Srdan Verstovsek, MD, PhD: Myelofibrosis is one of the myeloproliferative neoplasms, a chronic disease of the bone marrow. It is, unfortunately, the aggressive type. It does affect the life expectancy of the patients. The average survival is about 5 to 7 years.
Is telomerase good or bad?
Too much telomerase can help confer immortality onto cancer cells and actually increase the likelihood of cancer, whereas too little telomerase can also increase cancer by depleting the healthy regenerative potential of the body.
Where does the name Geron come from?
French: from the personal name Gero, Gerone, a short form of a Germanic personal name formed with gar, ger ‘spear’, ‘lance’, as for example Gérard (see Gerard).
What is the longest you can live with myelofibrosis?
Can you live a long life with myelofibrosis?
Life expectancy in PMF Primary myelofibrosis, also known as idiopathic myelofibrosis or myelofibrosis with myeloid metaplasia, is a rare disease19, 20 usually affecting elderly people. Median survival ranges from 4 to 5.5 years in modern series6, 7, 8, 9, 10, 11, 12, 13, 14 (Figure 1).