What does Glypican-3 do?
What does Glypican-3 do?
Glypican-3 is a useful diagnostic marker for a component of hepatocellular carcinoma in human liver cancer. Int J Oncol.
What is the function of Glypican?
Glypican-3 (GPC3) is a cell-surface glycoprotein consisting of heparan sulfate glycosaminoglycan chains and an inner protein core. It has important functions in cellular signaling including cell growth, embryogenesis, and differentiation.
What does vimentin stain?
Vimentin stains virtually all spindle cell neoplasms—mesenchymal spindle cell neoplasms and sarcomatoid carcinomas included. However, vimentin stains a subset of carcinomas regularly and to a significant degree, and this may be useful in the context of a panel of antibodies to narrow a differential diagnosis.
What are Syndecans and Glypicans?
Two major classes of proteoglycans contain heparan sulphate chains: syndecans, which have a transmembrane domain in their core proteins, and glypicans, which are attached to the cell membrane by glycosylphosphatidylinositol (GPI)-anchors.
What do proteoglycans do?
The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the molecule, which provides hydration and swelling pressure to the tissue enabling it to withstand compressional forces.
What does a positive vimentin mean?
Mesenchymal and endothelial cells usually stain vimentin positive and thus act as a measure of internal quality control in immunoreactivity. Absence of immunostaining in these areas often indicates that there is significant damage to tissue antigens and loss of structural architecture.
What is the function of Syndecan?
Syndecans function as coreceptors with growth factor or adhesion receptors and function to “tune” extracellular signal transfer across the cell surface to the cytoskeleton and cytoplasmic mediators to effect activation of a variety of intracellular signaling cascades.
What is a proteoglycan meaning?
Listen to pronunciation. (PROH-tee-oh-GLY-kan) A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide. Proteoglycans are found in cartilage and other connective tissues.
What is difference between glycoprotein and proteoglycan?
The main difference between proteoglycan and glycoprotein is that in proteoglycans, one or more glycosaminoglycan chains are attached to the protein while in glycoproteins, oligosaccharide chains are attached to proteins.