What does chromosome 17 indicate?

What does chromosome 17 indicate?

Human chromosome 17 is implicated in a wide range of human genetic diseases. It is home to genes involved in early-onset breast cancer (BRCA1), neurofibromatosis (NF1) and the DNA damage response (TP53 encoding the p53 protein).

What is DNA marker 17?

The RARA gene on chromosome 17 provides instructions for making a transcription factor called the retinoic acid receptor alpha (RARα). A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity (transcription) of particular genes.

What is 17p gene?

Chromosome 17p duplication is a chromosome abnormality that occurs when there is an extra copy of genetic material on the short arm (p) of chromosome 17. The severity of the condition and the signs and symptoms depend on the size and location of the duplication and which genes are involved.

What type of chromosome is 17?

Chromosome 17 spans more than 83 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DNA in cells….

Do Down syndrome have an extra chromosome?

Babies with Down syndrome have an extra copy of one of these chromosomes, chromosome 21. A medical term for having an extra copy of a chromosome is ‘trisomy. ‘ Down syndrome is also referred to as Trisomy 21.

Is 17p the same as p53?

A deletion of 17p commonly involves the tumor suppressor gene p53 on band 17p13. 1 with allelic loss of the gene. p53 is a tumor suppressor that induces cell-cycle arrest with following DNA repair or apoptotic cell death in response to genotoxic substances, oncogenes, hypoxia, DNA damage or ribonucleotide depletion.

How many base pairs are in chromosome 17?

83 million base pairs
Chromosome 17 spans more than 83 million base pairs (the building material of DNA) and represents between 2.5 and 3% of the total DNA in cells.