What does caveolin-1 do?
What does caveolin-1 do?
Through these pathways, caveolin-1 is involved in regulating cell growth and division (proliferation), the process by which cells mature to perform specific functions (differentiation), cell survival and the self-destruction of cells (apoptosis), and cell movement.
Where is caveolin-1 found?
Caveolin-1 (Cav-1) is a scaffolding protein and the main component of the caveolae plasma membranes in most cell types. The expression of Cav-1 is found in most normal organs but decreased when tissue is isolated or grown in culture (Carver & Schnitzer, 2003).
What does Cav-1 stand for?
6. Cav-1 (caveolin-1)—a scaffolding protein component of caveolae plasma membrane domains—plays an important positive role in the regulation of endothelial cell differentiation—a prerequisite step in the process of angiogenesis.
What is clathrin and caveolin?
Caveolae and clathrin-coated vesicles are both specialized regions of the plasma membrane, crucial to the endomembrane system within the cell. They are involved in the internalization of proteins and lipids, as well as other membrane trafficking between cellular organelles.
What is caveolin endocytosis?
Caveolar endocytosis is a clathrin-independent endocytic process which involves bulb-shaped, 50-60nm plasma membrane invaginations called caveolae (or ‘little caves’). Caveolae formation is driven by integral membrane proteins called caveolins as well as peripheral membrane proteins called cavins (reviewed in [1]).
What is the CAV3 gene?
The CAV3 gene provides instructions for making a protein called caveolin-3, which is found in the membrane surrounding muscle cells. This protein is the main component of caveolae, which are small pouches in the muscle cell membrane.
What is canine adenovirus?
Canine adenovirus type 2 (CAV-2) causes respiratory disease in dogs and is one of the infectious agents commonly associated with canine infectious tracheobronchitis, which is also known as kennel cough. Canine infectious tracheobronchitis is usually spread from dog to dog through coughing.
What is the difference between clathrin and caveolin endocytosis?
What is caveolin mediated endocytosis?
Caveolae-mediated endocytosis involves nanoparticles being trafficked to caveolae invaginations on the cell membrane which internalise the particle. Caveolae-mediated endocytosis appears to be a slower process than clathrin-mediated endocytosis although both processes result in similar size endosomes.
What is the function of caveolin-3?
Normal Function This protein is the main component of caveolae, which are small pouches in the muscle cell membrane. Within the caveolae, the caveolin-3 protein acts as a scaffold to organize other molecules that are important for cell signaling and maintenance of the cell structure.
Why are my muscles rippling?
Rippling muscle disease can be caused by mutations in the CAV3 gene. Muscle conditions caused by CAV3 gene mutations are called caveolinopathies. The CAV3 gene provides instructions for making a protein called caveolin-3, which is found in the membrane surrounding muscle cells.
What is the difference between adenovirus 1 and adenovirus 2?
An essential difference between canine adenoviruses 1 and 2 is that, whereas canine adenovirus 1 causes systemic disease, canine adenovirus 2 infection results only in restricted respiratory disease.