What are examples of reperfusion injury?
What are examples of reperfusion injury?
Table 1
| Affected organ | Example of clinical manifestation |
|---|---|
| Circulatory arrest | Hypoxic brain injury; multiple organ failure; acute kidney injury |
| Sickle cell disease | Acute chest syndrome; pulmonary hypertension, priapism, acute kidney injury |
| Sleep apnea | Hypertension; diabetes |
| Ischemia and reperfusion during major surgery |
What is the mechanism of reperfusion injury?
Reperfusion injury results from several complex and interdependent mechanisms that involve the production of reactive oxygen species, alterations in intracellular calcium handling, microvascular and endothelial cell dysfunction, altered myocardial metabolism, and activation of neutrophils, platelets and complement.
What is the main cause of reperfusion injury?
As this process is repeated, it eventually damages tissue enough to cause a wound. The main reason for the acute phase of ischemia-reperfusion injury is oxygen deprivation and, therefore, arrest of generation of ATP (cellular energy currency) by mitochondria oxidative phosphorylation.
How can reperfusion injury be reduced?
Potential therapies include pharmacological treatment, ischemic preconditioning, and the use of medical gases or vitamin therapy, which could significantly help experts develop strategies to inhibit ischemia reperfusion injury.
What are signs of reperfusion?
Early signs of reperfusion were ST-segment normalization (likelihood ratio 16.0), development of terminal T-wave inversion (likelihood ratio 10.6), accelerated idioventricular rhythm (likelihood ratio 6.0), and a twofold increase in ventricular premature complexes (likelihood ratio 2.5).
How can reperfusion injury be prevented?
First, optimizing CPR quality is a key component in order to limit reperfusion injury. Second, post-resuscitation care that targets normal oxygenation (avoiding hyper or hyopoxia), normocapnia, and normal blood pressure post ROSC seem to be of major importance.
How is reperfusion accomplished?
Coronary reperfusion is accomplished by primary PCI (angioplasty and stenting) or by IV fibrinolytic therapy.
What is an enhanced reperfusion injury?
Reperfusion injury is defined as local pulmonary edema seen by chest radiograph resulting from increased perfusion after relief of obstructed pulmonary blood flow, particularly in patients with MAPCAs who undergo PA rehabilitation.
How do you treat reperfusion injury?
What are the types of reperfusion therapy?
Reperfusion therapy using thrombolysis, including intravenous (IV) tissue plasminogen activator (tPA) and endovascular interventions such as mechanical thrombectomy (MT), are the only approved treatments for AIS. Both these treatment options have limitations when used as monotherapies.
What should be included in a reperfusion strategy?
Selecting the optimal reperfusion strategy requires customization based on patient factors including time from symptom onset to first medical contact (FMC), the amount of myocardium at risk, the presence of shock or severe heart failure, the risk of bleeding with fibrinolysis, and the time required to perform PCI ( …
What is the difference between reperfusion and revascularization?
Revascularization therapy is distinct from reperfusion therapy. The former takes place in non-ST-elevation or ST-elevation ACS, while reperfusion is employed only for ST-elevation myocardial infarction.