What are Chondrogenic cells?
What are Chondrogenic cells?
Two types of cell are formed during chondrogenesis: chondroblasts, and chondrocytes (Fig. 1). Chondroblasts are progenitor cells that secrete the extracellular matrix (ECM), while chondrocytes are involved in nutrient diffusion and matrix repair. Both cell types are required to form cartilage.
What is Chondrogenic induction?
Chondrogenic induction of human osteoarthritic cartilage-derived mesenchymal stem cells activates mineralization and hypertrophic and osteogenic gene expression through a mechanomiR – PMC.
Where are Chondrogenic cells found?
cartilage
Unsourced material may be challenged and removed. Chondrocytes (/ˈkɒndrəsaɪt, -droʊ-/, from Greek χόνδρος, chondros = cartilage + κύτος, kytos = cell) are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans.
What is Chondrogenic medium?
PromoCell Mesenchymal Stem Cell Chondrogenic Differentiation Media is a serum-free medium developed for the directed differentiation of mesenchymal stem cells (MSC) from bone marrow, the umbilical cord matrix (Wharton´s Jelly) and adipose tissue into chondrogenic lineages.
What are Chondrogenic progenitor cells?
Chondrogenic progenitor cells are a subpopulation of cells that are localized in the repair tissue of advanced stages of osteoarthritis (Koelling et al. 2009). The compositions of collagens change in the late stages of osteoarthritis.
How does chondrogenesis happen?
Chondrogenesis occurs as a result of condensation of mesenchymal cells, which express collagens I, III and V, and chondroprogenitor cell differentiation with expression of cartilage-specific collagens II, IX, and XI.
What is Chondrogenic tumor?
Chondrogenic tumors are the second largest group of bone tumors. Their histologic pattern suggests a relationship to hyaline cartilage. Exostoses, or osteochondromas, represent about 1/3 of chondrogenic lesions.
Is Aggrecan a gag?
Almost 90% of aggrecan mass is comprised of substituted GAG chains which are mostly chondroitin sulfate chains, but also include keratan sulfate chains with N- and O-linked oligosaccharides.
What are Chondroblasts?
Chondroblasts (AKA perichondrial cells) are cells that play an important role in the formation of cartilage (AKA chondrogenesis). They are located in the perichondrium, which is a layer of connective tissue that surrounds developing bone and also helps protect cartilage.
What membrane surrounds cartilage?
Cartilage, like bone, is surrounded by a perichondrium-like fibrous membrane.
What happens first during chondrogenesis?
As we mentioned previously, the first step in chondrogensis is cell condensation and the subsequent formation of condensed cell aggregates that occurs prior to chondrogenic differentiation [19], [20].