Is cytochrome c oxidase A heme protein?
Is cytochrome c oxidase A heme protein?
Cytochrome c is a heme protein that is localized in the compartment between the inner and outer mitochondrial membranes where it functions to transfer electrons between complex III and complex IV of the respiratory chain.
What is the role of the heme iron complex of cytochrome c in cellular respiration?
Cytochrome c is a component of the respiratory electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the bc1 Complex III and transports them to Complex IV, while it transfers energy (derived from O2) in the opposite direction.
Does cytochrome oxidase contain iron?
Abstract. Cytochrome oxidase from eukariots is a metallo-protein, integral to the mitochondrial membrane, which contains copper and iron. The basic functional unit of cytochrome oxidase contains four metals, two copper and two iron atoms, which are bound to the seven polypeptide chains in an unknown manner.
What is the role of cytochrome c?
Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis.
Why iron is used in cytochrome?
In the cytochromes, the iron which is coordinately linked with four nitrogen atoms within the prosthetic group and with two additional ligands provided by the protein moiety, can alternate between a reduced Fe2+ and an oxidized Fe3+ state.
What is the function of cytochrome c oxidase?
Cytochrome c oxidase or complex IV, catalyzes the final step in mitochondrial electron transfer chain, and is regarded as one of the major regulation sites for oxidative phosphorylation. This enzyme is controlled by both nuclear and mitochondrial genomes.
What metal ions are contained in cytochrome c oxidase?
Cytochrome C oxidase (CCO) is composed of 13 protein subunits. It contains three copper ions, which are necessary for its function. It also contains zinc, magnesium, and two heme groups.