How is succinylcholine packaged?
How is succinylcholine packaged?
Succinylcholine Chloride Injection USP 200 mg/10 mL (20 mg/mL) Preservative Free. This item is packaged with 5 pre-filled 10mL syringes per carton, 6 cartons per case, 30 syringes per case.
How much succinylcholine is in a vial?
Succinylcholine Chloride Injection, USP is supplied as a clear, colorless solution in 10 mL multiple-dose vials. Each mL contains succinylcholine chloride, USP 20 mg.
How do you administer succinylcholine?
Intramuscular Use. If necessary, succinylcholine may be given intramuscularly to infants, older children, or adults when a suitable vein is inaccessible. A dose of up to 3 to 4 mg/kg may be given, but not more than 150 mg total dose should be administered by this route.
How long can succinylcholine be out of fridge?
The results of our study show that the 20 and the 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts without refrigeration for about 8 and 5 months, respectively, without considerable loss of potency.
Is succinylcholine water soluble?
Succinylcholine chloride dihydrate crystals melt at 156–163°C. The anhydrous form melts at about 190°C. It is freely soluble in water (1 g/mL) and soluble in 95% ethanol (0.42 g/100 mL).
What is the use of succinylcholine?
Succinylcholine chloride is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Why is succinylcholine used in intubation?
To this day, succinylcholine is the only depolarizing agent used for rapid sequence induction. Because of its rapid onset, ultrashort duration of action, and safety, it is the paralytic of choice in almost all cases of rapid sequence induction in adults.
How much succinylcholine is lethal?
The 40-mg ampule dose of succinylcholine administered intramuscularly to the victims, possibly causing prolonged apnea, was considered to be at least around the minimum lethal dose, although the combined effect of the sedation with hypnotics also used was not negligible.
How fast do you push succinylcholine?
Dosing: Adults: 0.6 mg/kg (0.3 to 1.1) over 10-30 seconds, up to 150mg total dose.
Does succinylcholine need refrigeration?
Succinylcholine Chloride Injection, USP, should be stored in the refrigerator; if unbuffered succinylcholine chloride injection complying with USP pH limits must be stored at room temperature, it should not be kept for longer than four weeks.
Can succinylcholine be frozen?
Although freezing of succinylcholine is a rare event, the consequences may be hazardous especially in cases of rapid sequence induction.
Do you reverse succinylcholine?
Oxygen saturation can fall to critically low levels leading to cerebral and cardiac anoxia Faced with a CVCI (cannot intubate ,cannot ventilate) situation, reversal of succinylcholine induced paralysis can be life saving .