How is aspirin made step by step?
How is aspirin made step by step?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
How is aspirin made in industry?
Aspirin is the most widely sold over-the-counter drug. The production process involves the reaction of Salicylic acid and acetic anhydride in glass lined vessels. The liquid produced is pumped to a crystallizer, where it is cooled down to start the crystallization to Aspirin.
What is the reaction mechanism of aspirin?
The synthesis of aspirin is classified as an esterification reaction. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid’s hydroxyl group into an ester group (R-OH → R-OCOCH3).
How is aspirin prepared in laboratory?
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, sulfuric acid will be used as the catalyst. The excess acetic anhydride will be quenched (reacted) with the addition of water.
How is salicylic acid converted into aspirin?
For the preparation of aspirin, salicylic acid is reacted with an excess of acetic anhydride. Small amount of strong acid is used as a catalyst in these reactions which enhances the speed of reaction acid used is phosphoric acid. Excess acetic acid will be extinguished with the addition of water.
Where does aspirin come from?
History of aspirin It comes from Spiraea, a biological genus of shrubs that includes natural sources of the drug’s key ingredient: salicylic acid. This acid, resembling what’s in modern-day aspirin, can be found in jasmine, beans, peas, clover and certain grasses and trees.
What are the raw materials for aspirin?
Raw Materials To produce hard aspirin tablets, corn starch and water are added to the active ingredient (acetylsalicylic acid) to serve as both a binding agent and filler, along with a lubricant.
What plant is aspirin made from?
Abstract. The story of the discovery of aspirin stretches back more than 3500 years to when bark from the willow tree was used as a pain reliever and antipyretic.
How does aspirin work in the body?
Aspirin works by blocking the production of prostaglandins, the on-off switch in cells that regulate pain and inflammation, among other things. That’s why aspirin stops mild inflammation and pain.
What is hydrolysis of aspirin?
Aspirin (2-ethanoyloxybenzoic acid or acetylsalicylic acid) hydrolyses to produce 2-hydroxybenzoic acid and ethanoic acid.
Why is water added to synthesis of aspirin?
After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.