How do you dissolve Carbopol?
How do you dissolve Carbopol?
Using moderate to vigorous agitation (800-1200 rpm), add the oil phase containing Carbopol® polymer to the water phase. The water phase should contain an appropriate neutralizing base. Continue to mix for 15-20 minutes until the Carbopol® polymer has swelled to produce a smooth emulsion.
Is Carbopol a gelling agent?
The higher the concentration of carbopol, the greater is the structural viscosity. Carbomers are the most commonly used gelling agents in the manufacture of creams, ointments, and gels particularly meant for the application on mucous membranes.
Why is Carbopol a gelling agent?
Carbopol® is a synthetic polymer gel consisting of polyacrylic acid crosslink subunit. Because of the synthetic nature of Carbopol®, the physical properties are highly controllable and reproducible during manufacturing and higher stability than natural gelling agents when prepare as gel [8].
How do you make Carbopol gel?
Preparation of Glibenclamide gel The 100 g gel was prepared by direct dispersion method. In this firstly, propyl paraben was dissolved in water at 80ºC and then accurately weighed quantity of carbopol 940 was dispersed in water at 40ºC with constant stirring for 30 min [8].
Is Carbopol water soluble?
Carbopol® polymers are highly water and polar solvent soluble polymers which function as efficient thickeners and stabilizers for suspensions or emulsions. Much of the exceptional utility of the Carbopol® polymers results from the hydrophilic nature of the polymer.
How does Carbopol work in gel?
The gelling effect is activated in two stages, firstly the dispersion and hydration of the Carbopol, and secondly “neutralizing” the solution by the addition of chemicals which increase the pH. Neutralizing agents include triethanolamine (TEA), sodium hydroxide and potassium hydroxide.
What is the difference between Carbomer and Carbopol?
Carbopol 934 is cross-linked with allyl sucrose and polymerized in benzene. Carbopol 71, 971, and 974 are cross-linked with allylpentaerythritol and polymerized in ethyl acetate. Carbomer polymers contain 56%–68% of carboxylic acid (–COOH) groups and 0.75%–2% of cross-linking agents.
How do you make gel formulation?
Preparation of gel base Mixed 4.83 mL of propylene glycol in 12 mL of demineralized water with stirring for 10 min. Disodium edetate and triethanolamine solution were added to carbopol solution and the pH was then adjusted to 7.4 by stirring the solution for 10 min.
What is the viscosity of gel?
The viscosity of a regular UV or LED cured gel in nail products will range from approximately 25,000 centipoise to 100,000 centipoise. Centipoise is the unit of measurement for viscosity. A builder gel will have a higher viscosity than regular gel. Many builder gels have a viscosity of approximately 350,000 centipoise.
How do you test the viscosity of gel?
Viscosity is measured using a Marsh funnel, a conical-shaped funnel, fitted with a small-bore tube on the bottom end through which mud flows under a gravity head. A screen over the top removes large particles that might plug the tube.
What is the gel strength?
Gel strength can be defined as a measure of the ability of a colloidal dispersion to develop and retain a gel form based on its resistance to shear. From: Drilling Engineering, 2021.