How do I remove DCC urea?

How do I remove DCC urea?

Dissolve the compound in minimum amount of cold ACN and the precipitated DCU will be filtered. Repeat this process for 2-3 times to minimize the contamination of DCU in the compound.

Is DCC soluble in ethanol?

I have seen traces of DCCU even after chromatographic separation. These days I prefer DIC or HBTU over DCC. I have checked the solubility and the compound is soluble is DCM, Ethyl acetate, diethyl ether, chloroform, methanol and ethanol.

Is DCU soluble?

It is the byproduct of the reaction of dicyclohexylcarbodiimide with amines or alcohols. It may be prepared by the reaction of cyclohexylamine and S,S-dimethyl dithiocarbonate. 1,3-Dicyclohexyl urea (DCU) is a potent soluble epoxide hydrolase (sEH) inhibitor.

Is DCC soluble in DCM?

DCC is highly soluble in dichloromethane, tetrahydrofuran, acetonitrile and dimethylformamide, but insoluble in water.

How is urea removed from reaction mixture?

Since the urea is soluble in water, give repeated water wash followed by brine wash to remove urea present in the reaction mixture.

Is DMAP soluble in water?

DMAP – Nature 6kPa). Flash point 230 °c. Water soluble 76g/L (25 degrees C). Insoluble in water, hexane, cyclohexane, soluble in ethanol, benzene, chloroform, methanol, ethyl acetate, acetone, acetic acid and dichloroethane.

Is DCC water soluble?

It is highly soluble in dichloromethane, tetrahydrofuran, acetonitrile and dimethylformamide, but insoluble in water.

Is DCC soluble in acetonitrile?

Solubility: DCC: highly sol dichloromethane, THF, acetonitrile, DMF. DMAP: sol dichloromethane, THF, acetonitrile, DMF, ethyl acetate.

Is DCU soluble in acetonitrile?

Do the reaction in acetonitrile as the solvent, when the reaction has finished put the vessel in the fridge or freezer overnight and the DCU will crystallise out. You can then filter. This method is pretty efficient as apart from DCU most compounds I have come across are fairly soluble in acetonitrile.

How do you quench a DCC?

Add cold acetone or dissolve your compound in DCM and put it in a freezer. Adding ether will also do.

Is DCC soluble in DMSO?

DCC: mp 34–35 °C; bp 122–124 °C/6 mmHg. Solubility: DMSO: sol H2O, alcohol, acetone, CH2Cl2, THF.

What neutralizes urea?

Water is the single best method for neutralizing urea from pet urine. Water the lawn daily if multiple animals or strays are a concern.