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Can valproic acid cause hyponatremia?

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Can valproic acid cause hyponatremia?

Hyponatremia is a very commonly encountered clinical entity with potentially dangerous effects and for which many precipitating factors have been identified. We present a case of valproic acid (VPA) overdose causing profound hyponatremia, with one of the lowest serum sodium levels ever documented in literature.

Does sodium valproate affect sodium levels?

We conclude that sodium valproate can cause an SIADH-like syndrome with hyponatremia and that serum sodium levels have to be monitored during treatment with high dosages of this drug.

What are the two rare significant side effects of valproic acid?

Serious side effects

  • thoughts of harming or killing yourself – a small number of people taking valproic acid have had suicidal thoughts.
  • yellowing of the whites of your eyes or your skin, although this may be less obvious on brown or black skin, and dark pee – these may be signs of liver problems.

Which is major side effect of valproic acid?

Diarrhea, dizziness, drowsiness, hair loss, blurred/double vision, change in menstrual periods, ringing in the ears, shakiness (tremor), unsteadiness, weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What are the side effects of sodium valproate?

Common side effects

  • stomach pain, feeling or being sick.
  • diarrhoea.
  • dry or sore mouth, or swollen gums.
  • shakes (tremors) in a part of your body, or unusual eye movements.
  • feeling tired or sleepy.
  • headache.
  • weight gain.
  • thinning hair, or changes to the colour or texture of your hair.

Does divalproex cause low sodium?

Divalproex sodium (DVP) is an antiepileptic medication that also has mood stabilizing properties for patients with mental health disorders. Currently, there are a small number of case reports discussing the incidence of hyponatremia that occurs as an adverse effect of DVP.

What are the main side effects of sodium valproate?

What is the problem with valproate?

Research has shown that sodium valproate can cause serious problems in a developing baby. Of babies whose mothers take sodium valproate during pregnancy, up to 1 in 10 (10%) are at risk of having a birth defect, and up to 4 in 10 children (up to 40%) have problems with development and learning as they grow.

What are the contraindications of valproic acid?

Valproic acid is contraindicated in patients with hepatic disorders, significant hepatic impairment, hypersensitivity to components of the drug and class of drug, urea cycle disorders, mitochondrial disorders, or suspected disorders in patients <2-year-old, and pregnancy (for migraine headache prophylaxis use of …

What is the side effect of sodium valproate?

Taking too much sodium valproate can lead to symptoms such as: feeling or being sick (nausea or vomiting) headaches or feeling dizzy. muscle weakness.

What happens if you take too much valproic acid?

Valproic acid may cause serious or life-threatening damage to the pancreas. This may occur at any time during your treatment. If you experience any of the following symptoms, call your doctor immediately: ongoing pain that begins in the stomach area but may spread to the back nausea, vomiting, or loss of appetite.

What happens when valproic acid level is low?

The valproic acid level in the blood must be maintained within a narrow therapeutic range. If the level is too low, someone may experience a recurrence of symptoms, but, if the level is too high, someone may experience an increase in the number and severity of symptoms and side effects.