What is an inflammatory myofibroblastic tumor?

What is an inflammatory myofibroblastic tumor?

An Inflammatory myofibroblastic tumor (IMT) is an uncommon, usually benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age.

Is inflammatory myofibroblastic tumor a sarcoma?

Inflammatory myofibroblastic tumors usually occur in children and young adults. They are a type of soft tissue sarcoma.

What is inflammatory pseudotumor?

Inflammatory pseudotumors (IPTs) are rare, well-circumscribed, unencapsulated, quasi-neoplastic tumors of unregulated growth of inflammatory cells, first recognized by Umiker and Iverson.

What is epithelioid inflammatory myofibroblastic sarcoma?

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a variant of myofibroblastic tumor with malignant characteristics; it mainly consists of round-to-epithelioid cells with positive nuclear membrane/perinuclear immunostaining for anaplastic lymphoma kinase (ALK) receptor tyrosine kinase.

What is myofibroblastic spindle cell?

Histopathologically, myofibroblastic sarcomas (MFS) are composed of slender spindle cells with variable nuclear pleomorphism and mitotic activity. The spindle cells are arranged in interlacing fascicles and have eosinophilic cytoplasm, which may be occasionally wavy.

What is IMT in medical term?

Inflammatory Myofibroblastic Tumor (IMT)

What is myofibroblastic proliferation?

Pseudosarcomatous myofibroblastic proliferation (PMP) is a rare disease entity of unknown etiology and pathogenesis. PMP is also known as an inflammatory pseudotumor (IPT) or inflammatory myofibroblastic tumor (IMT), and it is characterized by myofibroblast proliferation and inflammatory cell infiltration.

How fast do benign tumors grow?

Benign tumors tend to grow slowly and have distinct borders. Benign tumors are not usually problematic. However, they can become large and compress structures nearby, causing pain or other medical complications.

How is inflammatory pseudotumor treated?

Corticosteroids and surgical resection are the mainstays of therapy for inflammatory pseudotumors of the head and neck. High-dose corticosteroids cause rapid decrease of inflammatory pseudotumor, but tumors recurred in 20% of patients with parapharyngeal space or skull base treated with corticosteroids.

Can a mass be inflammation?

Inflammatory conditions, such as rheumatoid arthritis, can also result in soft tissue masses. Even metabolic conditions, such as hyperlipidemia (high blood fat levels), can cause masses to form that may look like tumors.

What is a spindle cell?

(SPIN-dul sel TOO-mer) A type of tumor that contains cells called spindle cells, based on their shape. Under a microscope, spindle cells look long and slender. Spindle cell tumors may be sarcomas or carcinomas.

What causes intimal thickening?

Aging is a contributing factor to increased carotid intima-media thickness. Other risk factors include high lipoprotein levels, high blood pressure, smoking, diabetes, obesity and a sedentary lifestyle. Physicians use CIMT testing to determine the “age” of the carotid arteries.