What is the difference between raltegravir and dolutegravir?
What is the difference between raltegravir and dolutegravir?
The once-daily HIV integrase inhibitor dolutegravir demonstrated better efficacy than twice-daily raltegravir for previously treated people with HIV, with fewer study withdrawals due to virological failure and less emergent drug resistance, researchers reported on Wednesday at the 7th International AIDS Society …
What is raltegravir potassium used for?
Raltegravir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who weigh at least 4.5 lbs (2 kg). Raltegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in the blood.
How is dolutegravir metabolized?
In vitro, dolutegravir is primarily metabolized by UDP-glucuronosyltransferase (UGT) 1A1 and cytochrome P450 (CYP) 3A4 and at clinically relevant concentrations is not an inhibitor of CYP or UGT enzymes (12).
What type of inhibitor is raltegravir?
Raltegravir is an HIV strand transfer integrase inhibitor currently approved for HIV-1–infected, treatment-experienced adults with ongoing viremia and virus resistant to multiple other antiretroviral drugs.
Can dolutegravir be used as Pep?
Dolutegravir, raltegravir or rilpivirine as the 3rd drug: The current guidelines recommend dolutegravir or raltegravir or rilpivirine as the 3rd drug in PEP. Using three drugs for PEP increases the likelihood of an adverse event e.g. drug-drug interactions and the potential for rhabdomyolysis with raltegravir.
Does raltegravir have side effects?
Raltegravir can cause serious, life-threatening side effects. These include severe skin rash and allergic reactions and liver problems. Contact your health care provider right away if you develop a rash while taking raltegravir.
What is Dolutegravir used for?
Dolutegravir is used together with other medicines for the treatment of the infection caused by human immunodeficiency virus (HIV) in patients who have not received anti-HIV medicines in the past or to replace their current anti-HIV medicines. HIV is the virus that causes acquired immune deficiency syndrome (AIDS).
When calcium and dolutegravir was given together there is?
Description: Coadministration of calcium supplements decreased dolutegravir AUC, Cmax and C24 by 39%, 37% and 39%, respectively due to complex binding to polyvalent ions. Calcium supplements should be taken well separated in time from the administration of dolutegravir (minimum 2 hours after or 6 hours before).
Why is efavirenz better than dolutegravir?
The integrase inhibitor dolutegravir reduces HIV viral load to less than 50 copies per mL after a median of 28 days in non-pregnant adults, compared with 84 days for efavirenz.
Is raltegravir an integrase inhibitor?
Raltegravir is first in a novel class of antiretroviral drugs known as integrase inhibitors. It has demonstrated potent anti HIV activity in both antiretroviral treatment-naïve and experienced patients.
How long does dolutegravir stay in the body?
At 96 hours after the last dose, dolutegravir remained detectable in all participants and above the IC90 in 4 of 17. At 72 hours elvitegravir remained detectable in 9 of 17 participants, all below the IC90.
What is the best ARV combination?
A triple-drug combination of zidovudine, didanosine and nevirapine has been found to outperform combination therapy with two nucleosides as demonstrated by changes in the viral load and the CD4+ count.