General

What are the factors of dengue?

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What are the factors of dengue?

Factors believed to be responsible for the spread of dengue include the following:

  • Explosive population growth.
  • Unplanned urban overpopulation with inadequate public health systems.
  • Poor control of standing water and vectors.
  • Viral evolution.

Which strain of dengue is most virulent?

According to experts, dengue DENV-2 or D2 is known to be the most virulent strain and can cause severity in disease.

What are viral virulence factors?

Virus virulence factors allow it to replicate, modify host defenses, and spread within the host, and they are toxic to the host. They determine whether infection occurs and how severe the resulting viral disease symptoms are. Viruses often require receptor proteins on host cells to which they specifically bind.

What are the three types of risk factors for dengue severity?

Risk factors for severe dengue fever were secondary infection (p = 0.02), and co-morbidities, particularly diabetes and hypertension (p < 0.001).

What is the vector for dengue virus?

Aedes aegypti mosquito. Dengue viruses are spread to people through the bites of infected Aedes species mosquitoes (Ae. aegypti or Ae. albopictus).

What are environmental and host factors that can contribute to dengue?

No environmental factors are closely related to dengue incidence. The most prominent environmental factor associated with dengue cases is humidity, with moderate strength. Land cover, elevation, and rainfall have weak correlation with dengue cases. Temperature does not affect dengue cases.

Which dengue serotype is most severe?

Severe dengue affected 6.6 % of all cases, of which 32.3 % of the cases caused by DENV-2, 6.4 % of those caused by DENV-4, 4.5 % of those caused by DENV-1, and none of those caused by DENV-3. Severe dengue was found to be seven times more frequent among cases of DENV-2 than among those of the other serotypes.

What is serotype in dengue virus?

The Dengue Serotypes Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with the antibodies in human blood serum.

What are the 5 virulence factors?

5: Virulence Factors that Promote Colonization

  • The ability to use motility and other means to contact host cells and disseminate within a host.
  • The ability to adhere to host cells and resist physical removal.
  • The ability to invade host cells.
  • The ability to compete for iron and other nutrients.

What are the types of virulence factors?

Specific Virulence Factors

  • Adherence and Colonization Factors. To cause infection, many bacteria must first adhere to a mucosal surface.
  • Invasion Factors.
  • Capsules and Other Surface Components.
  • Endotoxins.
  • Structure of Endotoxin.

What is the pathogenesis of dengue fever?

Severe dengue most commonly occurs among patients with secondary DENV infections and infants with primary infections. The most widely-cited hypothesis for the pathogenesis of severe dengue is antibody-dependent enhancement (ADE).

How does dengue affect the body?

Severe dengue happens when your blood vessels become damaged and leaky. And the number of clot-forming cells (platelets) in your bloodstream drops. This can lead to shock, internal bleeding, organ failure and even death. Warning signs of severe dengue fever — which is a life-threatening emergency — can develop quickly.