What does pagetoid spread of a Tumour refer to?

What does pagetoid spread of a Tumour refer to?

Pagetoid spread, is used to define intraepithelial spread of cancer cells, when a massive carcinoma is identified beneath the basal membrane. There are only few reports of pagetoid spread at the head and neck region.

What is pagetoid spread in melanoma?

In superficial spreading melanomas, the Pagetoid distribution of melanocytes tends to spread over the breadth of the lesion, while it is more focal in benign melanocytic proliferations.

What is pagetoid scatter?

The pagetoid type is characterized by scattered individual or aggregates of large pleomorphic tumor cells with a vacuolated foamy cytoplasm and nuclei with dense chromatin within the epidermis or conjunctival epithelium. From: Encyclopedia of Cancer (Third Edition), 2019.

What is pagetoid dyskeratosis?

Pagetoid dyskeratosis is defined as the presence of pale cells resembling those of Paget disease in the epidermis. Pagetoid cells have a similar pagetoid appearance and intraepidermal spread of epithelial, melanocytic, neuroendocrine, lymphoid, and histiocytic lineage.

What is the meaning of perineural invasion?

Perineural invasion means that cancer cells were seen surrounding or tracking along a nerve fiber within the prostate. When this is found on a biopsy, it means that there is a higher chance that the cancer has spread outside the prostate.

What is Transcoelomic metastasis?

Transcoelomic (meaning “across the peritoneal cavity”) ▶metastasis refers to the dissemination of malignant tumors throughout the surfaces and organs of the abdominal and pelvic cavity covered by \peritoneum.

What does mitotic rate mean in melanoma?

In malignant melanoma, mitotic activity may probably indicate the depth of tumor invasion. Therefore, in incisional biopsies where depth of invasion cannot be accurately determined, the mitotic activity may be used to estimate Breslow thickness, which is necessary for planning surgical management.

How do you identify melanoma histology?

Histological features that favor a diagnosis of melanoma include asymmetry, ulceration, cytological atypia, pagetoid involvement of the epidermis, lack of maturation, and dermal mitosis with deep and atypical ones.

What happens in Paget’s disease?

Paget’s (PAJ-its) disease of bone interferes with your body’s normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, bones can become fragile and misshapen. The pelvis, skull, spine and legs are most commonly affected.

Who does Paget’s disease affect?

Paget’s disease most often affects older people, occurring in approximately 2 to 3% of the population over the age of 55. Many patients with Paget’s disease have no symptoms at all and are unaware they have the disease until X-rays are taken for some other reason.

What are Pagetoid cells?

Pagetoid is a term used in dermatology to refer to “upward spreading” of abnormal cells in the epidermis (ie from bottom to top). It is uncommon and a possible indication of a precancerous or cancerous condition. Cells display pagetoid growth when they invade the upper epidermis from below.

Does perineural invasion mean metastasis?

Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients.