What is HSL in lipolysis?
What is HSL in lipolysis?
Abstract. All treatments for obesity, including dietary restriction of carbohydrates, have a goal of reducing the storage of fat in adipocytes. The chief enzyme responsible for the mobilization of FFA from adipose tissue, i.e., lipolysis, is thought to be hormone-sensitive lipase (HSL).
How is lipolysis measured?
The most direct assessment of lipolysis is the measurement of the lipolytic products released by adipocytes or fat explants. This method is based on the measurement of lipolytic products (FAs and glycerol), which are released into the incubation media.
Where is hormone-sensitive lipase HSL expressed?
testis
HSL is an intracellular neutral lipase that is capable of hydrolyzing a variety of esters. The enzyme has a long and a short form. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production.
How do you activate the HSL enzyme?
High-Intensity Training. Sustained aerobic activity for longer than 15 to 20 minutes mobilizes fat from your bodily fat stores in response to decreasing glycogen levels in the blood. With decreased blood sugar levels, your insulin levels are depleted, thus triggering an increase of HSL.
What is HSL fat burning?
Hormone sensitive lipase (HSL) is an enzyme that regulates adipose tissue lipolysis and plays an important role in chronic exercise-induced changes in adipose tissue metabolism.
What is HSL disease?
Abstract. Fatty liver is a major health problem worldwide. People with hereditary deficiency of hormone-sensitive lipase (HSL) are reported to develop fatty liver. In this study, systemic and tissue-specific HSL-deficient mice were used as models to explore the underlying mechanism of this association.
What is lipolytic capacity?
Lipolytic capacity was related to fat cell size in women (P = 0.0008; r = 0.58), but not in men (P = 0.67; r = 0.086). The protein content of hormone-sensitive lipase, which determines lipolytic capacity, was significantly lower in obese men and women and increased slightly after weight reduction in men only.
How can I increase my HSL level?
Basal lipolysis, measured as glycerol release, did not increase until 2 days of fasting. HSL activity remained relatively unchanged until 3 days of fasting when it was increased twofold after 3-5 days of fasting. Likewise, HSL immunoreactive protein and HSL mRNA levels increased twofold after 3-5 days of fasting.
Does insulin increase HSL?
Acute insulin treatment could stimulate cAMP phosphodiesterase in an ATP-dependent manner, accelerating cAMP hydrolysis, suppressing PKA activity, and inhibiting PKA-dependent activation of HSL. A study performed by Holm and colleagues also confirmed that insulin could inhibit HSL lipolysis.