General

Is craniofacial fibrous dysplasia a tumor?

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Is craniofacial fibrous dysplasia a tumor?

Fibrous dysplasia was first described by Lichtenstein in 1938 as a disorder characterized by progressive replacement of normal bone elements by fibrous tissue. It is a bone tumor that, although benign, has the potential to cause significant cosmetic and functional disturbance, particularly in the craniofacial skeleton.

What is craniofacial dysplasia?

Craniofacial fibrous dysplasia is a bone disease of the face and skull that replaces normal bone with fibrous-type tissue. This tissue is not as hard as normal bone, and because it is soft and stringy, it makes the bone more fragile and prone to break.

How rare is craniofacial fibrous dysplasia?

CFD is a benign, slowly progressive bone disorder in which normal craniofacial bones are replaced by fibrous tissue in which secondary metaplastic bone formation occurs. [7] FD is relatively rare in the craniofacial region, (only 20% of all locations).

What are the symptoms of fibrous dysplasia?

What are the symptoms of fibrous dysplasia?

  • A waddling walk.
  • Bone deformity.
  • Bone fractures.
  • Bone pain (which happens when the fibrous tissue expands in the bone)
  • Scoliosis (a sideways curve of the spine)

What causes facial dysplasia?

Causes. Mutations in the ALX3 gene cause frontonasal dysplasia type 1, ALX4 gene mutations cause type 2, and ALX1 gene mutations cause type 3. These genes provide instructions for making proteins that are necessary for normal development, particularly of the head and face, before birth.

What causes cranial facial disorder?

Craniofacial malformations, including craniosynostosis, are the result of an infant’s skull or facial bones fusing together too soon or in an abnormal way. When the bones fuse together too early, the brain can become damaged as it grows and cannot expand properly, and the infant may develop neurological problems.

Is fibrous dysplasia serious?

Complications. Severe fibrous dysplasia can cause: Bone deformity or fracture. The weakened area of an affected bone can cause the bone to bend.

How serious is fibrous dysplasia?

Severe fibrous dysplasia can cause: Bone deformity or fracture. The weakened area of an affected bone can cause the bone to bend. These weakened bones also are more likely to fracture.