What is spectinomycin resistance?
What is spectinomycin resistance?
Spectinomycin is an aminocyclitol antibiotic which inhibits bacterial protein biosynthesis by reversibly binding to the 30S ribosomal subunit. Resistance to spectinomycin is commonly due to enzymes which inactivate the drug by adenylylation.
What do you mean by cross antibiotic resistance?
Definition of cross-resistance : tolerance (as of a bacterium) to a usually toxic substance (such as an antibiotic) that is acquired not as a result of direct exposure but by exposure to a related substance.
What is the function of spectinomycin?
Spectinomycin (336) is an effective antibiotic against gonorrhea infections. It functions by binding the 30S bacterial ribosomal subunit thus blocking ribosome translocation.
What is the mechanism of action of Spectinomycin?
Mechanism of action Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida.
How does Spectinomycin differ from the other aminoglycosides antibiotics?
Spectinomycin is an aminocyclitol antibiotic, which shares similar features with an aminoglycoside. However, it differs in that it does not contain amino sugars or glycosidic bonds. It has a broad spectrum of activity. It is highly water soluble and is easily mixed in aqueous solutions.
What is the difference between MIC and MBC?
MIC is defined as the lowest concentration of antimicrobial or drug that will inhibit the visible growth of bacteria after overnight incubation (Levison, 2004), while MBC is the lowest concentration of antibacterial agent required to kill a particular bacterium (Wiegand et al., 2008).
Why is cross resistance important?
Due to cross-resistance, antimicrobial treatments like phage therapy can quickly lose their efficacy against bacteria. This makes cross-resistance an important consideration in designing evolutionary therapies.
What is the mechanism of action of spectinomycin?
How do you administer spectinomycin?
Adults (Men and Women) Inject 5 mL intramuscularly for a 2-gram dose. This is also the recommended dose for patients being treated after failure of previous antibiotic therapy. In geographic areas where antibiotic resistance is known to be prevalent, initial treatment with 4 grams (10 mL) intramuscularly is preferred.