What is SULT enzyme?

What is SULT enzyme?

The superfamily of sulfotransferase (SULT) enzymes catalyzes the sulfate conjugation of several pharmacologically important endo- and xenobiotics. SULT1A1 catalyzes the sulfation of small planar phenols such as neurotransmitters, steroid hormones, acetaminophen, and p-nitrophenol (PNP).

What is sulfotransferase activity?

sulphotransferase activity. Definition: Catalysis of the transfer of a sulfate group from 3′-phosphoadenosine 5′-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3′-phosphoadenosine 5′-phosphate.

Where are sulfotransferase located?

the Golgi
PAPS is a cosubstrate and source of activated sulfate for both cytosolic sulfotransferases and carbohydrate sulfotransferases, which are located in the Golgi.

What is the cofactor for Sult?

The formation of the latter species is catalyzed by sulfotransferases (SULTs), which for their activity depend on the cofactor 3′-phosphoadenosine-5′-phosphosulfate (PAPS).

What is sulfation in biology?

Sulfation is an important pathway of metabolism for a range of endogenous compounds including steroid hormones, bile acids, neurotransmitters, and small peptides. Xenobiotics also undergo conjugation by sulfation, which generally, but not exclusively, leads to reduced biological activity.

What is Glucuronidation reaction?

Glucuronidation is a conjugation reaction whereby glucuronic acid, derived from cofactor UDP-glucuronic acid, is covalently linked to a substrate containing a nucleophilic functional group. The resultant metabolite, called a glucuronide, is usually excreted in bile and urine.

What is the meaning of sulfated?

1. To treat or react with sulfuric acid or a sulfate. 2. Electricity To cause lead sulfate to accumulate on (the plates of a lead-acid storage battery).

What is the difference between sulfonation and sulfation?

Sulfonation and sulfation are two important chemical processes used in many industries to add a sulfur-containing group to an organic compound. The main difference between sulfonation and sulfation is that sulfonation involves the formation of a C-S bond whereas sulfation involves the formation of a C-O-S bond.

What is glucuronidation and sulfation?

Sulfation and glucuronidation are the principal metabolic pathways of flavonoids, and extensive phase II metabolism is the main reason for their poor bioavailabilities.

Which drugs are Glucuronidated?

Affected drugs

• Amitriptyline.
• Clomipramine.
• Clonazepam.
• Diazepam.
• Flunitrazepam.
• Lorazepam.
• Nitrazepam.
• Oxazepam.

What is another word for sulfates?

In this page you can discover 16 synonyms, antonyms, idiomatic expressions, and related words for sulphate, like: sulfate, chloride, cupric, phosphate, dichromate, hydroxide, molybdate, ferric, ammonium, magnesium and hcl.

Is there a difference between sulfate and sulphate?

“Sulfate” is the spelling recommended by IUPAC, but “sulphate” was traditionally used in British English.