What is p63 on a tumor?
What is p63 on a tumor?
Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.
What is p63-positive in lung?
p63 is a recently discovered member of the p53 family that has been shown to be important in the development of epithelial tissues. p63 may also play a role in squamous cell carcinomas of the lung, head and neck, and cervix, and its expression is increased in these tumors.
What does negative for p63 mean?
Clinical Information. The p63 protein is a member of the p53 family of tumor-suppressor proteins. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63.
What is p40 and p63?
In summary, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma.
What is p63 a marker for?
Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the identification of myoepithelial cells in other tissues including the breast. p63 is also a marker for squamous cell carcinoma.
What is the function of p63?
The p63 protein functions as a transcription factor, which means it attaches (binds) to certain regions of DNA and controls the activity of particular genes. The p63 protein interacts with other proteins to turn many different genes on and off at different times.
What is p63 Immunostain?
The p63 protein is a member of the p53 family of tumor-suppressor proteins. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63.
What does p63 positive mean in breast?
P63 is a positive prognostic factor in endocrine-treated ER positive breast cancer and might influence responsiveness to endocrine treatment. Thus, p63 could be helpful as a predictive factor for endocrine therapy.
What is p63 positive in breast?
What is p63 in breast biopsy?
Abstract. p63, a member of the p53 gene family, is involved in cellular differentiation and is expressed in the nuclei of myoepithelial cells of normal breast ducts and lobules.
What is p63 positive myoepithelial cells?
p63-positive myoepithelial cells have been shown to surround benign epithelial lesions and form a consistent, although discontinuous, rim around epithelial cells in carcinomas in situ. No staining has been noted in infiltrative carcinomas.
Should I have a mastectomy for DCIS?
In most cases, a woman with DCIS can choose between breast-conserving surgery (BCS) and simple mastectomy. But sometimes, if DCIS is throughout the breast, a mastectomy might be a better option. There are clinical studies being done to see if observation instead of surgery might be an option for some women.
What are the most common types of p63 positive tumors?
The highest frequencies of p63 positivity were seen in squamous cell carcinomas irrespective of their origin, thymic tumors, urothelial cancers and basal type tumors such as basal cell carcinomas and various salivary gland neoplasia. A detailed description of the immunostaining results is given in Table Table11and Fig. 3.
What is the significance of p63 In pathology?
In diagnostic pathology, the consistently high expression of p63 in specific cell and tissue types is exploited for diagnostic purposes. For example, p63 immunohistochemistry (IHC) is commonly used to mark cell types with critical impact on cancer diagnosis such as basal cells in prostatic and breast glands.
Is p63 a marker of metaplastic cancer?
p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. p63, a member of the p53 gene family, is involved in cellular differentiation and is expressed in the nuclei of myoepithelial cells of normal breast ducts and lobules.
Why is p63 high in adnexal tumours?
As mentioned previously, p63 is expressed in the basal cells of cutaneous appendages in normal skin, therefore, high expression can be expected in adnexal tumours. Indeed, multiple studies have confirmed the presence of p63 in these tumours and proposed the utility of p63 for distinguishing CANs from metastatic carcinoma to skin.