What are GLI transcription factors?
What are GLI transcription factors?
The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription.
What does Gli stand for biology?
The activity of Smo affects the bifunctional glioma-associated oncogene transcription factors (Gli), which are transcriptional effectors of the Hh pathway.
What is GLI Hedgehog pathway?
The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical role in controlling cell specification, cell–cell interaction and tissue patterning during embryonic development.
What does GLI3 gene do?
It plays a role in cell growth, cell specialization, and the patterning of structures such as the brain and limbs. Depending on signals from Sonic Hedgehog, the GLI3 protein can either turn on (activate) or turn off (repress) other genes.
How does cyclopamine inhibit Shh?
Cyclopamine impacts embryonic development by hindering the sonic hedgehog (Shh) pathway. In healthy development, the Shh gene codes for Shh proteins. These proteins have a high affinity for a surface membrane protein called “Patched”. Upon binding, Shh proteins inhibit Patched.
Why is it called Sonic hedgehog gene?
The gene was named by Robert Riddle, a postdoctoral fellow at the Tabin Lab, after his wife Betsy Wilder came home with a magazine containing an advert for the game Sonic the Hedgehog.
Why is it called Hedgehog pathway?
The pathway takes its name from its polypeptide ligand, an intracellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila; fruit fly larva lacking the Hh gene are said to resemble hedgehogs.
Where is Gli3 gene located?
Chromosome 7
GLI3
| Gene location (Human) | ||
|---|---|---|
| Chr. | Chromosome 7 (human) | |
| Band | 7p14.1 | 41,960,949 bp |
| 42,264,100 bp |
How does Gli3 enter the nucleus?
Initiation of signaling triggers the dissociation of Sufu from Gli3. This event prevents formation of the repressor and instead allows Gli3 to enter the nucleus, where it is converted into a labile, differentially phosphorylated transcriptional activator.
Is Sonic hedgehog a morphogen?
Sonic hedgehog (Shh), along with members of the Wnt and bone morphogenetic protein (BMP) families, is a molecule that acts early as a morphogen to determine neuronal fate and later as an axon guidance factor to help direct the paths of developing neurons (Figure 1).
What does Sonic hedgehog do?
Specifically, Sonic Hedgehog establishes the midline for the underside (ventral surface) of the forebrain. Sonic Hedgehog and other signaling proteins are needed to form the right and left halves (hemispheres) of the brain. Sonic Hedgehog also has an important role in the formation of the eyes.
Is Sonic a mutant?
In his Archie Comics continuity, it was eventually revealed that Sonic the Hedgehog was a mutant with human DNA, and that Mobius was a future Earth.