Questions

What drugs are estrogen blockers?

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What drugs are estrogen blockers?

Aromatase inhibitors are a class of medicines that reduce the amount of estrogen in your body, depriving breast cancer cells of the hormones they need to grow….Medications that stop the body from making estrogen after menopause

  • Anastrozole (Arimidex).
  • Exemestane (Aromasin).
  • Letrozole (Femara).

What is the mechanism of action of tamoxifen?

Tamoxifen (TAM) is known to have a dual mechanism of action: (1) to compete with 17β-estradiol (E2) at the receptor site and to block the promotional role of E2 in breast cancer; and (2) to bind DNA after metabolic activation and to initiate carcinogenesis.

What does tamoxifen do to the body?

Tamoxifen is a type of hormonal therapy known as a selective estrogen receptor modulator (SERM). The drug attaches to hormone receptors (specific proteins) in breast cancer cells. Once the medication is inside the cells, it stops the cancer from accessing the hormones they need to multiply and grow.

Can tamoxifen cause depression?

Many of the treatments breast cancer patients undergo can also trigger symptoms of depression. For example, tamoxifen can affect a patient’s hormone levels causing depression. Ironically, some antidepressants can interfere with tamoxifen’s ability to treat the disease.

What are the long term side effects of tamoxifen?

Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported.

What are natural estrogen blockers?

Citrus fruits – including oranges, lemons, grapefruits, and mandarins – are rich in vitamin C and antioxidants that help inhibit the production of estrogen levels in the body to correct hormonal imbalances. Chrysin. Passion flowers, honeycombs, and certain mushrooms contain the flavonoid chrysin.

What are the most common side effects of tamoxifen?

Tamoxifen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • increased bone or tumor pain.
  • pain or reddening around the tumor site.
  • hot flashes.
  • nausea.
  • excessive tiredness.
  • dizziness.
  • depression.
  • headache.

What drugs should not be taken with tamoxifen?

Certain medications used to treat depression should be avoided by women taking tamoxifen. The antidepressants paroxetine (Paxil) and fluoxetine (Prozac) have been found to increase women’s risk of dying of cancer if they are taking tamoxifen.

Does tamoxifen cause depression?

Tamoxifen is known to trigger depressive symptoms as a result of its anti-estrogenic activity.

How does tamoxifen make you feel?

Some people have indigestion or mild nausea (feeling sick). This is usually most noticeable when they start taking tamoxifen. These symptoms generally improve or become easier to manage over time and may be helped by taking the tamoxifen with food or taking it at a different time of day.