What is CD45 function?

What is CD45 function?

CD45 is now established as a critical component of the signal transduction machinery of lymphocytes. In particular, evidence from genetic experiments indicates that CD45 plays a pivotal role in antigen-stimulated proliferation of T lymphocytes and in thymic development.

What cells are CD45 +?

CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling.

What is Ptprc gene?

PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Hepatitis C Virus.

What does CD45 bind?

T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 activates Lck by opposing the negative regulatory kinase Csk.

Is CD45 a receptor?

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

Is CD45 a phosphatase?

Transmembrane protein tyrosine phosphatases, such as CD45, can act as both positive and negative regulators of cellular signaling. CD45 positively modulates T cell receptor (TCR) signaling by constitutively priming p56lck through the dephosphorylation of the C-terminal negative regulatory phosphotyrosine site.

What is the difference between CD45RA and CD45RO?

Typically CD45RA and CD45RO are run against each other and against CD3 and CD4 or CD8. This is a 5-color flow cytometry study. CD45RA is the long isoform of CD45 and is expressed on naive T cells. CD45RO is the shorter isoform, and is expressed on T cells that have encountered antigens.

What are CD11c cells?

CD11c is a type I transmembrane protein that is expressed on monocytes, granulocytes, a subset of B cells, dendritic cells, and macrophages and may be demonstrated on B-cell chronic lymphocytic leukemia, marginal zone lymphomas, and hairy cell leukemia.

What are CD16 monocytes?

Classical monocytes, characterized by expression of CD14++CD16-, represent about 80% of all monocytes and have phagocytic function, with production of reactive oxygen species and secretion of pro- and anti-inflammatory cytokines in response to agonist stimulation of toll-like receptor-4 (TLR-4) [6].

Is CD16 an antibody?

CD16 Monoclonal Antibody (3G8), APC.